PB/AG Nanoemulsion: An Antimalarial Supplemental Aid

Published: Wednesday, 14 August 2024 Last Modified: Thursday, 5 December 2024

Congratulations to Prof. Stephanie Chan Yen San of Curtin University Malaysia for the SRDC-funded project titled "Enhancement of Antimalarial Property of Alpinia galanga Extract through Nanoemulsion Formulation with Essential Oils of P. Nigrum, C. Odontophyllum, N. sativa, C. Domestica, and P. Betle" (RDCRG/CAT/2019/04) on receiving the Silver Award at the 2024 Malaysia Technology Expo's: Advanced Healthcare and Life Sciences International Innovation Awards and Expo under the Diseases category!  

This project has filed a Patent - PI 2023007639 in 2023. The research project is a collaboration between Curtin University Malaysia and Unimas. 

From the results, the FTIR revealed good compatibility and Encapsulation for the PB/AG Extract in Nano Emulsion. While the GC-MS results complemented it revealing an abundance of Carboxylic Acids Flavonoids, and Phenols. The Nano Emulsion was further characterized and produced the following data. The PB/AG Nano Emulsion is also stable for up to 90 days. Next, the product demonstrated excellent in vitro drug release and permeability as compared to the aqueous control.  Besides, the product also showed great Antimalarial efficacy against Malaria Parasites along with a low Cytotoxicity against human cells in vitro. The results for the PB/AG Nano Emulsion showed immense potential and offer a convenient and non-invasive alternative to Conventional Antimalarial Drugs.  It could work as a supplement in itself or supplementing current treatments.  It presents as a candidate for further research as an Antimalarial Drug.